PET to Measure the Tisular Extent of Gene Therapy for Recurrent Glioblastoma
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PET to Measure the Tisular Extent of Gene Therapy for Recurrent Glioblastoma |
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| From Jacobs A et al. Lancet 2001 Sep 1;358(9283):727-9 | |
| Positron-emission tomography (PET) with I-124-labelled 2'-fluoro-2'-deoxy-1b-D-arabino-furanosyl-5-iodo-uracil ([124I]-FIAU), a specific marker substrate for gene expression of herpes simplex virus-1 thymidine kinase (HSV-1-tk) | |
| Before Liposome-HSV-1-tk infusion | After Liposome-HSV-1-tk infusion |
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| Coregistration of FIAU-PET, MET-PET, FDG-PET, and MRI before (left column) and after (right column) vector application. As seen in the images below, the region of specific [124I]-FIAU retention (68 h) within the tumour after Liposome-HSV-1-tk-complex transduction (white arrow) showed the signs of necrosis (cross hairs, right column; reduced methionine uptake [MET] and glucose metabolism [FDG]) after ganciclovir treatment. | |
| Before ganciclovir treatment | After ganciclovir treatment |
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