SPECT Patterns in Epilepsy

From Lee HW et al. Brain 2000;123:2150-59

Various perfusion patterns of subtracted SPECT in temporal and extra-temporal lobe epilepsy patients are illustrated

(A) hyperperfusion in only mesial temporal region of right mesial temporal lobe epilepsy (TLE) (B) hyperperfusion in lateral temporal region of a left neocortical TLE

Conventional interictal SPECT of (B)

Ictal SPECT of (B)
(C) hyperperfusion in both mesial and lateral temporal areas in a right mesial TLE (D) hyperperfusion-plus pattern of subtracted SPECT: bilateral temporal hyperperfusion with left predominance in a left neocortical TLE (E-1 and E-2) Combined hyperperfusion–hypoperfusion pattern of subtracted SPECT; E-1 is a positive image showing hyperperfusion in left anterior temporal region and E-2 is a negative image showing hypoperfusion in left posterior and basal lateral temporal cortex from the same interictal and ictal SPECT images
(F) focal hyperperfusion in a left supplementary motor area seizure

Interictal SPECT of (F)

Ictal SPECT of (F)
(G) focal hypoperfusion in a right frontal lobe epilepsy

Interictal SPECT of (G)

Ictal SPECT of (G)