Decreased Activation of Entorhinal Cortex on fMRI in MCI

Small SA et al. Ann Neurol 1999;45:466
Normal Mild Cognitive Impairment Alzheimer´s Disease
Note activation of all regions in normals and of none in AD. In MCI that do not deteriorate to AD (+EC) there is entorhinal activation, not present in MCI who deteriorate (-EC).