Entorhinal Metabolism as a Predictor of MCI or AD
From: DeLeon et al. PNAS 2001; 98: 10966

PET superimposed to MRI Entorhinal ROI drawn on MRI

Baseline PET in 12 subjects with MCI who in a follow up of 3 years developed progressive cognitive impairment (declining), compared to 13 subjects of similar age who did not

Regions
Baseline PET (METglu data: slab normalized regional means)
Non-Declining
Declining
P
Entorhinal Cortex
91 ± 7
75 ± 7
< 0.01
Hipocampus
90 ± 6
87 ± 5

 
STG
105 ± 3
103 ± 4

 
LTL
97 ± 7
91 ± 8

 
OFL
101 ± 15
102 ± 8

 
DFL
117 ± 9
109 ± 12

 
 
Illustration of the location of the entorhinal region from Killiany R et al. Neurology 2002;58:1188 The entorhinal cortex was the only region explored that at baseline had lower metabolism in the subjects who declined. This finding agrees with the finding that about 30% of entorhinal neurons are lost in people with MCI (Gomez-Isla T et al J Neurosc 1996)