MRI in Creutzfeldt-Jakob disease

MRI and neuropathology studies of two patients, one with sporadic and other with new-variant Creutzfeldt-Jakob disease. Both had the same imaging findings.

Haik S, Dormont D, Faucheux BA, Marsault C, Hauw JJ. Prion protein deposits match magnetic resonance imaging signal abnormalities in Creutzfeldt-Jakob disease. Ann Neurol. 2002;51:797-9.

FLAIR MRI Diffusion-weighted MRI Apparent diffusion coefficient (ADC) map

High-signal abnormality in

  • putamen

  • dorsomedial thalamus

  • Similar abnormalities, which on neuropathology corresponded to areas with high accumulation of abnormal prion protein