University of Navarra
Department of Genetics SCHOOL OF SCIENCES
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Research
PUBLICATIONS by members of the Department over the last 5 years.
 
 
Research Lines
  • Genetic mechanisms of tyrosine kinase activation in hematological neoplasms. Integrity of the JAK/STAT signal transduction pathway and clinical implications.
  • Large scale bioinformatic analysis of genes involved in chromosomal translocations in cancer.
  • Conventional and molecular cytogenetic analyses in hematological malignancies: search for new chromosomal rearrangements and evaluation of diagnostic and prognostic implications.
  • Identification and characterization of genes involved in the initiation and progression of hematological malignancies.
  • New cytogenetic and molecular techniques in the characterization of acute myeloid leukemias.
  • Prognostic value of chromosome 3p rearrangements in patients with myeloid neoplasms.
Research Projects currently active

Genetic Mechanisms de-regulating proteins with tyrosine kinase activity in Hematological Neoplasia. State of JAK-STAT pahtway and clinical implications.
-Lead Researcher:  José Luis Vizmanos Pérez
-Start Date: 2005 End Date: 2008
-Financing Entity: Proyectos de Investigación de la Universidad de Navarra (Proyectos PIUNA). Línea Especial.


The research project “Analysis of the genetic mechanisms causing a type of leukemia” has been chosen by 4,316 clients of the bank Caja Navarra, as part of the program "Tú eliges, tú decides [You choose, you decide]", among a total of 1,306 projects with a grand total of 440,760 euros. Many thanks to all those who have shown confidence in us and in our work.

We would like to thank all institutions that have supported our research over the years, both the research projects (Caja Navarra Foundation, PIUNA, FIS, CICYT, MEC, AECC and Government of Navarra) and the graduate students (Association of Friends of the University of Navarra, MEC, Government of Navarra, Basque Government and AECI).

Doctoral dissertations (since 2000)

José Ignacio Martín Subero. Development of the multicolor FICTION technique. Applications to the diagnosis and research of malignant lymphomas. Academic Year 2000-2001. Doctorado europeo. Directors: Reiner Siebert and María José Calasanz Abínzano. Premio Extraordinario de Doctorado.

Guillermo García del Barrio. Development of new pharmaceutical systems for gene transfer to muscle. Academic Year 2001-2002. Directors: Juan Manuel Irache Garreta and Francisco Javier Novo Villaverde.

Miguel Ángel Zaratiegui Biurrun. Development of viral vectors for gene transfer into the muscle and its use in distinct biological models. Academic Year 2001-2002. Director: Francisco Javier Novo Villaverde.

Sergio Portal Núñez. Development of peptidic inhibitors of the hepatitus C virus NS3a (VHC). Academic Year 2002-2003. Directors: Marina García Delgado y Francisco Borrás Cuesta.

Xabier Agirre Ena. Analysis of mutations, state of methylation and detection of the gene TP53 in acute lymphoblast leukemia. Academic Year 2002-2003. Directors: José Luis Vizmanos Pérez and Marina García Delgado. Premio Extraordinario de Doctorado.

Esther Andión Ibáñez. Study of the prognostic and predictive value of the resistance to agents alkylating the MGMT y TP53 genes in a series of high grade astrocytomas. Academic Year 2002-2003. Directores: Jesús García Foncillas y José Luis Vizmanos Pérez.

Idoya Lahortiga Ayerra. Molecular characterization of chromosomal rearrangements in acute myeloid leucemia. Análisis of the regions 1p36, 11p15, 12p13 y 16p13. Academic Year 2003-2004. Doctorado europeo. Directores: María Dolores Odero de Dios y María José Calasanz Abínzano. Premio Extraordinario de Doctorado.

Jorge Muñoz Aranda. Analysis of homozygous deletions, promoter methylation and genome damage in tumors from the nervous system. Academic Year 2003-2004. Director: Javier Sáez Castresana.

Maria Mar Inda Pérez. Different Genetic Profiles Determined in Supratentorial PNET, Medulloblastomas, and Neuroblastic Tumors. Academic Year 2003-2004. Doctorado europeo. Director: Javier Sáez Castresana. Premio Extraordinario de Doctorado.

Mikel Valgañón Petrizán. Analysis of TP53 and genetic and moleculary caracterización of 54 pacientes with chronic lymphoid leukemia in stages III and IV treated with first line fludarabine. Academic Year 2004-2005. Directors: María Dolores Odero de Dios and María José Calasanz Abínzano.

Borja Sáez Ochoa. Molecular cytogenetic characterization of chromosomal changes in Multiple Lyeloma. New insights into pathogenesis and diagnosis. Academic Year 2005-2006. Doctorado europeo. Directors: Reiner Siebert and María José Calasanz Abínzano.